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Zenrelia for Dogs

Not actual size.

Zenrelia (ilunocitinib tablets)

Zenrelia is a prescription medication that relieves itching in dogs due to allergic dermatitis and helps control atopic dermatitis. The active ingredient, ilunocitinib, reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy.

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Don’t Let Allergic Itch Disrupt Your Dog’s Zen. Reach for Zenrelia.

Itching, scratching and paw-licking? Dog allergies and canine dermatitis can make your dog uncomfortable. Zenrelia can help get them back to normal. Zenrelia is a prescription medication used to control itching and inflammation associated with skin allergies for dogs over 12 months of age. Normal defined as reducing itch and inflammation to normal levels where they do not disrupt daily life (PVAS<2 and CADESI-4<10).

Once-Daily Tablet

The oral tablet is given once a day with or without food — right from the comfort of your home. Always follow your veterinarian’s instructions.

Zenrelia Rapidly Controls Itch1

Zenrelia visibly improves itch fast,1 and it is designed to deliver continuous efficacy over the long term to help get your dog back to normal.2

Controls Allergic & Atopic Dermatitis

Zenrelia relieves itching in dogs due to allergic dermatitis and helps control atopic dermatitis. It reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy.

Dosage Options

Zenrelia tablet sizes doses: 4.8mg (6.05mm width, 11.10mm length); 6.4mg (6.30mm width, 11.63mm length); 8.5mg (7.04mm width, 12.75mm length); 15mg (8.86mm width, 15.70mm length). The tablet illustrations above are for visual reference only and not actual size.

There’s itch relief. Then there’s Zerelia

Zenrelia is supplied in 4 strengths and is dosed once daily at 0.27-0.36 mg/lb (0.6-0.8 mg/kg). Consult your veterinarian to determine the ideal dosage based on your dog's weight.

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Product Details

  • Zenrelia relieves itching in dogs due to allergic dermatitis and controls atopic dermatitis.
  • Ilunocitinib, the active ingredient in Zenrelia, works by reducing the itch and inflammatory response in your dog's skin due to allergies.
  • The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.
  • The once-daily tablet can be given with or without food from the comfort of your home.
  • Zenrelia works fast, providing visible improvements in itch.1


Zenrelia is a once-daily tablet that relieves itching due to allergic dermatitis and controls atopic dermatitis. The active ingredient, ilunocitinib, reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy. What's more, Zenrelia is designed to deliver continuous efficacy over the long term and can get your dog back to normal.2

The once-daily tablet can be given with or without food. Always follow your veterinarian's instructions.

Zenrelia is for dogs at least 12 months of age.

Uses
Zenrelia is a prescription medication used to control itching and inflammation associated with skin allergies for dogs over 12 months of age.

Possible Side Effects
Always follow your veterinarian's instructions. The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information. Zenrelia is a prescription itch relief medication for dogs at least 12 months of age. Ask your veterinarian if Zenrelia can relieve itching in your dog due to allergic and atopic dermatitis.

Precautions
Dogs should be up to date on vaccinations prior to starting Zenrelia (see Target Animal Safety Information). The safe use of Zenrelia has not been evaluated in breeding, pregnant, or lactating dogs. Decreased prostate gland weights in intact male dogs were observed in a laboratory safety study (see Target Animal Safety Informarion). The safe use of Zenrelia has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.

Package Insert

ilunocitinib

Follow your veterinarian's instructions. Normally, the dose of Zenrelia (ilunocitinib tablets) is 0.27 to 0.36 mg ilunocitinib/lb (0.6 to 0.8 mg ilunocitinib/kg) body weight, administered orally, once daily, with or without food.

Storage Instructions
Store at room temperature between 15 to 25°C (59 to 77°F), excursions permitted between 5 to 40°C (41 to 104°F).

Important Safety Information

INDICATIONS: Zenrelia is a prescription medication used to control itching and inflammation associated with skin allergies for dogs over 12 months of age.

See package insert including the Boxed Warning. For full prescribing information speak with your veterinarian, call 1-888-545-5973 or visit www.elancolabels.com/us/zenrelia.

WARNING: VACCINE-INDUCED DISEASE AND INADEQUATE IMMUNE RESPONSE TO VACCINES. Based on results of the vaccine response study, dogs receiving Zenrelia are at risk of fatal vaccine-induced disease from modified live virus vaccines and inadequate immune response to any vaccine. Discontinue Zenrelia for at least 28 days to 3 months prior to vaccination and withhold Zenrelia for at least 28 days after vaccination. Dogs should be up to date on vaccinations prior to starting Zenrelia. Do not use in dogs less than 12 months old or dogs with a serious infection. Dogs should be monitored for the development of infections because Zenrelia may increase the chances of developing an infection. Neoplastic conditions (benign and malignant) were observed during clinical studies. The most common side effects were vomiting, diarrhea and tiredness. Zenrelia has not been tested in dogs used for breeding, pregnant, or lactating dogs and has not been evaluated in combination with glucocorticoids, cyclosporine, or other immune suppressive drugs.

Frequently Asked Questions

Zenrelia is a JAK inhibitor for control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. It is an oral tablet, dosed once daily at 0.6-0.8 mg/kg.

Zenrelia is rapidly absorbed after oral administration and begins to work after the first dose, with visible improvements in itch from Day 1.*

Data on file

Yes. Dogs with food allergies were included in the allergic dermatitis clinical field trial conducted for FDA approval. Allergic dermatitis is an umbrella term that encompasses many different pruritic skin conditions in dogs, including canine atopic dermatitis (AD), ectoparasite hypersensitivity (flea allergy dermatitis, sarcoptic mange), food allergy dermatitis, and contact dermatitis. Dogs included in the clinical field trial could have one or more of these conditions.

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Discount Prescription Guide
Powered by Costco Health Solutions. Costco Member Prescription Program (CMPP) is a direct-to-members savings program administered by Costco Health Solutions, Inc. and Ventegra Inc. Participating pharmacies are subject to change without notice and are not available in all areas. CMPP is not insurance or intended as a replacement for insurance. Claims submitted for coverage under publicly funded programs (e.g. Medicare, Medicaid, etc.) or private insurance are not eligible for CMPP participation. Shipping and handling cost are not included in the price. Costco Health Solutions, Inc. 845 Lake Drive Issaquah, WA 98027 https://www.costcohealthsolutions.com/. Forster S, Boegel A, Despa S, et al. Comparative efficacy and safety of ilunocitinib and oclacitinib for the control of pruritus and associated skin lesions in dogs with atopic dermatitis. Veterinary Dermatology. 2025; 1–10 Normal defined as reducing itch and inflammation to normal levels where they do not disrupt daily life (PVAS<2 and CADESI-4 <10).